S-3-hydroxyphenyl (N-hydroxycarbamamido) (diphenyl) ethanethioate derivatives as potential inhibitors of 5 -Lipoxygenase (5-LOX)

Authors

  • Ariza-Rua, Danilo
  • Rebollo, Juan Alberto
  • Chavarro-Mesa, Edisson
  • Ballestas-Casallas, Yamil

DOI:

https://doi.org/10.18687/LACCEI2023.1.1.1222

Keywords:

5-Lipoxygenase, molecular docking, anti-inflammatory drugs

Abstract

We have designed and docked derivatives of a new anti-inflammatory compound into the crystal structure of the Lipoxygenase-5 (LOX-5) enzyme. We found that four derivatives have the same ability to inhibit the activity of the enzyme as the anti-inflammatory drug Zileuton. This information may help us develop new compounds to treat inflammation.

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Published

2024-04-16

Issue

Vol. 1 No. 8 (2023): LACCEI 2023

Section

Articles

How to Cite

Ariza-Rua, Danilo, Rebollo, Juan Alberto, Chavarro-Mesa, Edisson, & Ballestas-Casallas, Yamil. (2024). S-3-hydroxyphenyl (N-hydroxycarbamamido) (diphenyl) ethanethioate derivatives as potential inhibitors of 5 -Lipoxygenase (5-LOX). LACCEI, 1(8). https://doi.org/10.18687/LACCEI2023.1.1.1222

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