S-3-hydroxyphenyl (N-hydroxycarbamamido) (diphenyl) ethanethioate derivatives as potential inhibitors of 5 -Lipoxygenase (5-LOX)
DOI:
https://doi.org/10.18687/LACCEI2023.1.1.1222Palabras clave:
5-Lipoxygenase, molecular docking, anti-inflammatory drugsResumen
We have designed and docked derivatives of a new anti-inflammatory compound into the crystal structure of the Lipoxygenase-5 (LOX-5) enzyme. We found that four derivatives have the same ability to inhibit the activity of the enzyme as the anti-inflammatory drug Zileuton. This information may help us develop new compounds to treat inflammation.
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2023-07-27
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Derechos de autor 2023 LACCEI
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Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-CompartirIgual 4.0 Internacional.
LACCEI conserva el copyright de todos los artículos publicados bajo los términos de su acuerdo de transferencia de copyright. Como titular del copyright, LACCEI distribuye los artículos al público bajo la Licencia Internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0 (CC BY-NC-SA 4.0).
Cómo citar
Ariza-Rua, Danilo, Rebollo, Juan Alberto, Chavarro-Mesa, Edisson, & Ballestas-Casallas, Yamil. (2023). S-3-hydroxyphenyl (N-hydroxycarbamamido) (diphenyl) ethanethioate derivatives as potential inhibitors of 5 -Lipoxygenase (5-LOX). LACCEI, 1(8). https://doi.org/10.18687/LACCEI2023.1.1.1222